In the 70's, the boy Billy is born with yellow skin due to a liver disease and his dysfunctional mother rejects him. Later he witnesses his mother and her lover killing his beloved father and burying him in the basement of their house, and he is locked in the attic alone along his childhood. When he is a teenager, he is sexually abused by his mother and she has a baby girl called Agnes. During Christmas, the deranged Billy escapes from his imprisonment, kills his mother and stepfather and blinds one eye of Agnes. He is declared insane and his sister is sent to an orphanage. In the present days, Billy escapes from the Clark Sanatorium to spend Christmas with his family. Meanwhile, his former house is the Delta Alpha Kappa sorority house in the campus of the Clement University, and the housemother and the sisters Kelli Presley, Dana, Lauren Hannon, Megan, Heather, Megan Helms, Melissa and Eve Agnew are preparing the house for Christmas party in a stormy night while Clair Crosby is in her room writing a card to bury the hatchet with her sister. When three sisters vanish, the others receive weird phone calls and believe something is wrong, but they find that they are trapped in the location.