Sameer 'Sam' Kapoor (Abhishek Bachchan) and Kunal Chopra (John Abraham) are fun-loving, womanizer bachelors settled in Miami. Sam is a nurse by profession and is often joked around by others about the cliché 'skirt wearing' joke. Kunal is a photographer and is in look out for apartment after his partner asks him to move out within 2 weeks. They both briefly meet each other at a friend's place after a night out with girls. Later, they run into each other while looking for an apartment to rent and they both love it. The apartment belongs to Neha Melwani (Priyanka Chopra) who works for Verve magazine. She lives there with her Maasi (meaning Aunty in Hindi) (Sushmita Mukherjee). However, her Maasi refuses to sublet the apartment to either of them as Neha wanted only girls as her flat-mates.Being rejected the apartment, they walk out to a hot-dog stand where a homosexual American soldier mentions how much Sam and Kunal remind him of his own relationship with his long-term partner. Sam tries to persuade Kunal to pretend they are lovers so that they may live in the apartment. Kunal initially refuses but, desperate for the apartment, he agrees to it. Their plan works and they move in. One thing leads to another and they end up declaring themselves as 'gay' on official forms for permits of residence. Soon, the three of them become good friends. Gradually, both of them fall in love with Neha.Neha's boss, Murli 'M' (Boman Irani), resigns his job as the editor and says that the decision about the new editor is in his hands. To impress him, Neha invites her homosexual boss for dinner at her house, telling him that she will introduce him to her friends. The evening starts off fun and even an officer from the U.S. government who comes for a surprise, random inspection joins them. But the party soon turns into chaos when Rani (Kiron Kher) Sam's embarrassing mother drops by to check on her son after receiving a letter at her home in London from the U.S. government confirming approval for her son's application for domestic partnership with Kunal, only to discover her son's sexual preferences. The night comes to end when M discovers neither Sam not Kunal is actually single.The next day at Neha's office, M announces that Abhimanyu 'Abhi' Singh (Bobby Deol) is to be the new editor. Neha, deeply upset at being passed over for promotion, returns home where she is consoled by Rani. In turn, Neha helps her embrace her son's sexuality. Kunal and Sam, then help Neha with a project assigned by Abhi. Clearly impressed by Neha, Abhi announces that the success of the project is because of her. Later, Sam surprises her with late night amusement park trip and gifts her an album with their memories together.Sam and Neha go shopping. While she in the changing-room, he musters the courage to tell her he loves her from outside. She does not hear him, instead Kunal does. After overhearing Sam's confession, he quickly puts a stop to his conversation with her, telling him that he too loves Neha. Kunal hatches a plan for Neha's birthday party and misleads Sam to a night-bar, so that he can take Neha on what he hopes to make a date. Sam spends the entire night at the strip club being an eye candy at Maasi's kitty party. Neha perceives the dates with both guys as no more than a friendly outing, since she is convinced of their homosexuality. The next morning Sameer gets furious with Kunal and the tension between the two baffles Neha.Abhi and Neha start dating. Sam and Kunal decide to team up and sabotage their budding relationship. They give inappropriate advices to drive her interest off him. And his weird mannerisms, irrirates Neha and they end up having an argument. After she discovers the men behind these chaos are Kunal and Sam, she misinterprets it as their interest in Abhi. Despite their efforts, Abhi and Neha fall in love. Sam and Kunal redirect their efforts into frightening Abhi's five-year-old son, Veer, about his future if his father marries Neha and he gains Neha as a stepmother. Neha discovers that Abhi plans to propose to her during a basketball game. Before half-time she pulls Kunal and Sameer aside and asks them for advice. The pair is shocked and tell her to say a 'no', admitting that they are not homosexual, and in fact, are each in love with her. Meanwhile, Veer tells Abhi of his fears, begging his father not to marry Neha. During the game, Abhi hugs Neha and ends the relationship, citing Veer's discomfort. Neha tearfully evicts Kunal and Sameer from her apartment and resigns from "Verve."A few months later, Kunal and Sam meet each other at court to collect their resident permits and realise that though they don't have a romantic relationship with each other or with Neha, they shared a wonderful friendship, which is incomplete without Neha. Kunal and Sam reconcile. The two find Neha at a fashion show and try to apologise, but she refuses to see them. Abhi appears and Kunal asks when their wedding is. Neha tells him that they broke up because Veer's insecurity. Kunal and Sam reveal their misdeeds about manipulating Veer's mind, which angers both Neha and Abhi. Kunal and Sam climb onto the stage and beg for Neha's forgiveness. The crowd encourages them to beg plea on their knees, say that they love her, blow kisses to her, but nothing softens her. Finally, the crowd asks them to kiss each other, and they refuse. Neha and Abhi turn to leave and Kunal forcibly kisses Sam. Abhi is amazed and Neha, gets impressed at the length the two will stretch themselves to in order to regain her trust and she forgives them. Kunal and Sam, desperate to secure Neha's happiness and friendship, each get down on their knees and propose to Abhi on her behalf. Abhi, amused, agrees.Two months later, the friends trio are knocking back beers on a sunny day. Neha playfully asks the two whether they might have felt anything for each other in the time they spent pretending to be homosexual. The men get defensive and Neha tickled, takes her leave with a "Sorry, touchy topic." Sam and Kunal, now alone, remember their kiss.