Atropa Belladonna 50 Fresh SeedsAtropa belladonna or Atropa bella-donna, commonly known as Belladonna or Deadly Nightshade, is a perennial herbaceous plant in the family Solanaceae, native to Europe, North Africa, and Western Asia. The foliage and berries are extremely toxic, containing tropane alkaloids. These toxins include scopolamine and hyoscyamine which cause a bizarre delirium and hallucinations, and are also used as pharmaceutical anticholinergics. The drug atropine is derived from the plant.It has a long history of use as a medicine, cosmetic, and poison. Before the Middle Ages, it was used as an anesthetic for surgery; the ancient Romans used it as a poison (the wife of Emperor Augustus and the wife of Claudius both were rumored to have used it to murder contemporaries); and predating this, it was used to make poison-tipped arrows. The genus name "atropa" comes from Atropos, one of the three Fates in Greek mythology, and the name "bella donna" is derived from Italian and means "beautiful woman" because the herb was used in eye-drops by women to dilate the pupils of the eyes to make them appear seductive. Atropa belladonna is a branching herbaceous perennial, often growing as a subshrub, from a fleshy rootstock. Plants grow to 1.5 metres (4.9 ft) tall with 18 centimetres (7.1 in) long ovate leaves. The bell-shaped flowers are tyrian purple with green tinges and faintly scented. The fruits are berries, which are green ripening to a shiny black, and approximately 1 centimetre (0.39 in) in diameter. The berries are sweet and are consumed by animals that disperse the seeds in their droppings, even though the seeds contain toxic alkaloids. There is a pale yellow flowering form called Atropa belladonna var. lutea with pale yellow fruit.Atropa belladona is rarely used in gardens, but when grown, it is usually for its large upright habit and showy berries. It is naturalized in parts of North America, where it is often found in shady, moist locations with limestone-rich soils. It is considered a weed species in parts of the world, where it colonizes areas with disturbed soils. Germination of the small seeds is often difficult, due to hard seed coats that cause seed dormancy. Germination takes several weeks under alternating temperature conditions, but can be sped up with the use of gibberellic acid. The seedlings need sterile soil to prevent damping off and resent root disturbance during transplanting. The name Atropa belladonna was published by Linnaeus in Species Plantarum in 1753. It is in the nightshade family (Solanaceae), which it shares with potatoes, tomatoes, eggplants, jimsonweed, tobacco, wolfberry, and chili peppers. The common names for this species include belladonna, deadly nightshade, divale, dwale, banewort, devil's berries, naughty man's cherries, death cherries, beautiful death, devil's herb, great morel, and dwayberry.The name Atropa is thought to be derived from that of the Greek goddess Atropos, one of the three Greek fates or destinies who would determine the course of a man's life by the weaving of threads that symbolized his birth, the events in his life and finally his death; with Atropos cutting these threads to mark the last of these. The name "belladonna" comes from the Italian language, meaning "beautiful lady"; originating either from its usage as cosmetic for the face, or, more probably, from its usage to increase the pupil size in ladies.Belladonna is one of the most toxic plants found in the Eastern Hemisphere. All parts of the plant contain tropane alkaloids. The berries pose the greatest danger to children because they look attractive and have a somewhat sweet taste. The consumption of two to five berries by children and ten to twenty berries by adults is probably lethal. The root of the plant is generally the most toxic part, though this can vary from one specimen to another. Ingestion of a single leaf of the plant can be fatal to an adult.The active agents in belladonna, atropine, hyoscine (scopolamine), and hyoscyamine, have anticholinergic properties. The symptoms of belladonna poisoning include dilated pupils, sensitivity to light, blurred vision, tachycardia, loss of balance, staggering, headache, rash, flushing, severely dry mouth and throat, slurred speech, urinary retention, constipation, confusion, hallucinations, delirium, and convulsions. In 2009, A. belladonna berries were mistaken for blueberries by an adult woman; the six berries she ate were documented to result in severe anticholinergic syndrome. The plant's deadly symptoms are caused by atropine's disruption of the parasympathetic nervous system's ability to regulate involuntary activities, such as sweating, breathing, and heart rate. The antidote for belladonna poisoning is physostigmine or pilocarpine, the same as for atropine.Atropa belladonna is also toxic to many domestic animals, causing narcosis and paralysis. However, cattle and rabbits eat the plant seemingly without suffering harmful effects. In humans, its anticholinergic properties will cause the disruption of cognitive capacities, such as memory and learning.The common name belladonna originates from its historic use by women - Bella Donna is Italian for beautiful lady. Drops prepared from the belladonna plant were used to dilate women's pupils, an effect considered attractive. Belladonna drops act as an antimuscarinic, blocking receptors in the muscles of the eye that constrict pupil size. Belladonna is currently rarely used cosmetically, as it carries the adverse effects of causing minor visual distortions, inability to focus on near objects, and increased heart rate. Prolonged usage was reputed to cause blindness.Belladonna has been used in herbal medicine for centuries as a pain reliever, muscle relaxer, and anti-inflammatory, and to treat menstrual problems, peptic ulcer disease, histaminic reaction, and motion sickness. At least one 19th-century eclectic medicine journal explained how to prepare a belladona tincture for direct administration to patients.Belladonna tinctures, decoctions, and powders, as well as alkaloid salt mixtures, are still produced for pharmaceutical use, and these are often standardised at 1037 parts hyoscyamine to 194 parts atropine and 65 parts scopolamine. The alkaloids are compounded with phenobarbital and/or kaolin and pectin for use in various functional gastrointestinal disorders. The tincture, used for identical purposes, remains in most pharmacopoeias, with a similar tincture of Datura stramonium having been in the US Pharmacopoeia at least until the late 1930s. The combination of belladonna and opium, in powder, tincture, or alkaloid form, is particularly useful by mouth or as a suppository for diarrhoea and some forms of visceral pain; it can be made by a compounding pharmacist, and may be available as a manufactured fixed combination product in some countries (e.g., B&O Supprettes). A banana-flavoured liquid (most common trade name: Donnagel PG) was available until 31 December 1992 in the United States.Scopolamine is used as the hydrobromide salt for GI complaints, motion sickness, and to potentiate the analgesic and anxiolytic effects of opioid analgesics. It was formerly used in a painkiller called "twilight sleep" in childbirth.Atropine sulphate is used as a mydriatic and cycloplegic for eye examinations. It is also used as an antidote to organophosphate and carbamate poisoning, and is loaded in an autoinjector for use in case of a nerve gas attack. Atropinisation (administration of a sufficient dose to block nerve gas effects) results in 100 per cent blockade of the muscarinic acetylcholine receptors and atropine sulphate is the benchmark for measuring the power of anticholinergic drugs.Hyoscyamine is used as the sulphate or hydrobromide for GI problems and Parkinson's disease. Its side effect profile is intermediate to those of atropine and scopolamine, and can also be used to combat the toxic effects of organophosphates.Scientific evidence to recommend the use of A. belladonna in its natural form for any condition is insuffiicient, although some of its components, in particular l-atropine which was purified from belladona in the 1830s, have accepted medical uses. Donnatal is a prescription pharmaceutical, approved in the United States by the FDA, that combines natural belladonna alkaloids in a specific, fixed ratio with phenobarbital to provide peripheral anticholinergic/antispasmodic action and mild sedation. According to its labeling, it is possibly effective for use as adjunctive therapy in the treatment of irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and acute enterocolitis.